The San Francisco 49ers were defeated 35-10 by the Buffalo Bills in a snowstorm, with Josh Allen leading the charge with four total touchdowns. Allen threw for 148 yards and two touchdowns, ran for another touchdown, and even scored as a receiver in a dominant performance. The Bills improved to 10-2 and clinched a playoff spot. For the 49ers, running back Christian McCaffrey suffered a knee injury and linebacker Fred Warner also left the game due to injury. In other games, the Pittsburgh Steelers secured a 44-38 win over the Cincinnati Bengals, while Russell Wilson led the Seattle Seahawks to a 9-3 record with a 414-yard, three-touchdown performance. Jacksonville Jaguars quarterback Trevor Lawrence was carted off with a head injury in a loss to the Houston Texans, with the illegal hit leading to the ejection of Texans linebacker Azeez Al-Shaair. Overall, the week saw twelve games decided by seven points or less, the most in NFL history, with teams like the Colts, Vikings, and Buccaneers securing victories in the final minutes.
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