Brown University researchers have developed a groundbreaking new method for mass spectrometry that significantly reduces sample loss, improving accuracy and sensitivity. The nanopore ion source created by the team allows ions dissolved in water to be transferred directly into the mass spectrometer’s vacuum, avoiding the messy process of producing a spray of droplets.
The key component of the innovation is a tiny capillary with an opening roughly 1,000 times smaller than a human hair, allowing for efficient ion transfer with minimal gas intake. This advancement has the potential to revolutionize mass spectrometry technology by simplifying hardware and enabling more sensitive analyses, like sequencing amino acids in proteins one by one.
Over a decade of work led to the successful demonstration of the new transfer method, matching conventional ion analysis but with significantly less sample loss. The researchers aim to further develop their nanopore ion source to improve proteomic analyses and enhance research in the field. The team’s persistence and innovative approach have garnered attention for their groundbreaking work in the field of mass spectrometry.
The study, published in Nature Communications, showcases the potential of the new method to transform scientific research by providing a more efficient and accurate way to analyze tiny particles, opening up new possibilities for protein sequencing and proteomic analyses. The team’s dedication to overcoming challenges and developing cutting-edge technology highlights the impact of their work on the field of mass spectrometry.
Source
Photo credit astrobiology.com
